Applying meaningful real time analysis techniques to novel drug delivery systems can often be challenging. However, the ability to verify the physicochemical properties of these formulations both in the development phase and during production is critical. With a delivery system that involves drug inclusion in a carrier molecule, the verification of that inclusion is vital to the maintenance of the pharmacological integrity of the formulation. The work shown in this paper suggests that Raman based spectrometers enabled by the High-Throughput Virtual Slit (HTVS) can be useful for in situ real time verification of the inclusion complex formation. This makes it a potentially valuable PAT tool for the verification of the proper manufacture of these formulations.
