The QTrap 6500+ LC-MS/MS system from Sciex has improved sensitivity and selectivity for small molecule quantitation and integrates with their BioBA solution for large molecule quantitation. New features include the multi-component IonDrive technology with the new IonDrive high energy detector; its increased detection area produces sensitivity improvements in positive-ion ionisation and significant ones in negative mode in the low mass region. The scan function of MS3 adds an additional level of mass filtering, and the new SelexIon+ ion mobility technology (which now has a 2× increase in ion transmission) provides an orthogonal separation prior to mass separation.