The Thermo Scientific FAIMS Pro Duo interface enhances signal-to-noise ratios and expands sample coverage, allowing users to explore complex samples with reduced matrix interference. Additionally, optimal performance across a wide range of chromatographic flow rates (100 nL min–1 to 1 mL min–1) has benefits in areas such as proteome coverage, quantitative analysis, and more recently, glycoproteomics, single-cell proteomics and structural biology. The FAIMS Pro Duo interface easily integrates with Thermo Fisher’s mass spectrometers, including the Thermo Scientific Orbitrap Tribrid, Thermo Scientific Orbitrap Exploris, Thermo Scientific TSQ Altis and Thermo Scientific TSQ Quantis.