Bruker has announced new developments for spatial multiomics of tissue and tumour microenvironments (TME). Following Bruker’s strategic partnership with AmberGen, enhancements have been introduced for MALDI HiPLEX-IHC mass spectrometry imaging. MALDI HiPLEX-IHC represents a breakthrough in multiomics imaging by combining targeted protein expression spatial profiling with unbiased small molecule MALDI imaging to co-localise proteins and small molecules such as glycans, lipids, metabolites or xenobiotics. Using AmberGen’s Miralys™ antibody-based photocleavable peptide mass tags, highly multiplexed IHC staining and photocleavage of peptide markers fit seamlessly into Bruker’s IntelliSlide®-based automated workflows for MALDI imaging.
