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Intabio has announced a co-marketing and equipment loan agreement with Agilent Technologies to support development of integrated iCIEF-MS assays by interfacing Intabio’s Blaze™ to the Agilent 6545XT AdvanceBio LC/Q-TOF mass spectrometer. The combination of the Blaze system coupled to the Agilent 6545XT for the monitoring of Critical Quality Attributes (CQAs) on intact proteins will significantly increase productivity for biotherapeutic developers. Intabio’s Blaze system couples imaged capillary isoelectric focusing (iCIEF) and high-resolution mass spectrometry (MS) to provide a single 15-minute assay with 100 times the throughput of traditional workflows.
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![Targeted proton transfer charge reduction (tPTCR) nano-DESI mass spectrometry imaging of liver tissue from orally dosed rat (Animal 3). a) optical image of a blood vessel within liver tissue. b) Composite ion image of charge-reduced haeme-bound α-globin (7+ and 6+ charge states; m/z 2259.9 and m/z 2636.3 respectively, red) and the charged-reduced [FABP+bezafibrate] complex (7+ and 6+ charge states; m/z 2097.5 and m/z 2446.9 respectively, blue). c) Ion image composed from charge-reduced haeme-bound α-globin (7+ and 6+ charge states) showing abundance in blood vessels. d) Ion image composed from charge-reduced [FABP+bezafibrate] complex (7+ and 6+ charge states) showing abundance in bulk tissue and absence in the blood vessel. Reproduced from https://doi.org/10.1002/ange.202202075 under a CC BY licence. Light and mass spectromert imaging of tissue samples](/sites/default/files/styles/thumbnail/public/news/MSI%20drug-protein%20complex-w.jpg?itok=CBNIjyYl)




