MOBILion Systems is partnering with Agilent Technologies to integrate its ion mobility separations technology, called Structures for Lossless Ion Manipulation (SLIM), with Agilent’s Q-TOF mass spectrometry platform as the company’s first commercial product offering. This is the first of several partnerships through which MOBILion will integrate its ion mobility capabilities with mass spectrometry platforms.
MOBILion’s technology increases the capabilities of current liquid chromatography-mass spectrometry (LC-MS) analytical workflows, enabling multi-dimensional analysis of biologically relevant molecules with high levels of resolution and throughput. SLIM technology can be integrated with LC-MS workflows to provide more robust analytical information, and for some applications, replace liquid chromatography providing superior speed, ease-of-use and resolution.
A beta model will launch in 2020 with broader commercial availability planned for 2021.
SLIM technology was invented in the lab of Dr Richard D. Smith at Pacific Northwest National Laboratory. MOBILion has an exclusive license to offer SLIM technology for life science applications.




![Targeted proton transfer charge reduction (tPTCR) nano-DESI mass spectrometry imaging of liver tissue from orally dosed rat (Animal 3). a) optical image of a blood vessel within liver tissue. b) Composite ion image of charge-reduced haeme-bound α-globin (7+ and 6+ charge states; m/z 2259.9 and m/z 2636.3 respectively, red) and the charged-reduced [FABP+bezafibrate] complex (7+ and 6+ charge states; m/z 2097.5 and m/z 2446.9 respectively, blue). c) Ion image composed from charge-reduced haeme-bound α-globin (7+ and 6+ charge states) showing abundance in blood vessels. d) Ion image composed from charge-reduced [FABP+bezafibrate] complex (7+ and 6+ charge states) showing abundance in bulk tissue and absence in the blood vessel. Reproduced from https://doi.org/10.1002/ange.202202075 under a CC BY licence. Light and mass spectromert imaging of tissue samples](/sites/default/files/styles/thumbnail/public/news/MSI%20drug-protein%20complex-w.jpg?itok=CBNIjyYl)




