Microsaic Systems has introduced the 4500 MiD® chip-based mass spectrometer, which is designed for point-of-need analyses. The 4500 MiD combines the vacuum system, electronics and computer in one box, with no need for a floor pump. The new system offers an increased mass range (50–1400 m/z), a completely tool-less front-end and intuitive user interface. In addition, a change in front-end alignment has strengthened system uptime whilst reducing the deposition of contaminants downstream.