Bruker have introduced new SCiLS Cloud and SCiLS Lab mass spectrometry imaging (MSI) software solutions, now with MultiVendor Support. MALDI imaging has rapidly developed as a label-free technique for spatially resolved molecular analysis of proteins, glycans, lipids, as well as drugs and their metabolites. MALDI imaging is finding rapidly increasing use in pharmaceutical drug development, in tissue-resolved biomarker research (e.g. glycans on cell surfaces as cancer markers), as well as in translational pathology research to complement immunohistochemistry (IHC). The new SCiLS Cloud software offers web-based tools to facilitate distributed workflows, where data and analysis results can be shared, viewed and manipulated with a web browser through secure access. SCiLS Lab provides advanced and user-friendly solutions for data handling, visualisation and computational analysis for Bruker MALDI imaging data sets, and now also offers support for data acquired from non-Bruker mass spectrometers.